Skin Harmony Estriol Face Serum




Benefits of Hyaluronic Acid

Hyaluronic Acid is a natural substance in skin that has the stunning capacity to attract and hold vast amounts of moisture. It works overtime by replenishing skin to enhance a healthy look and feel.

Benefits of Hyaluronic Acid

As we age, our skin loses the ability to preserve moisture, resulting in the visible loss of firmness, pliability, and plumpness. Hyaluronic Acid swoops in with the ability to replenish moisture that is crucial to having younger-looking, supple skin.

At the same time, it revitalizes skin’s outer layers so they look and feel softer, smoother, and, glowingly hydrated to instantly improve the appearance of fine lines and wrinkles.

Dive Deeper In the world of skincare, trendy ingredients come and go, and many of them should never have shown up in the first place! Hyaluronic Acid is NOT one of those ingredients. Quite the contrary, it’s one of the most extraordinarily beneficial ingredients. Its calming, hydrating, and antioxidant properties are great for all skin types, even for rosacea-prone and eczema-prone skin.

Simply put, Hyaluronic Acid has powerful anti-aging properties and is also one of the premier hydrating ingredients for skin, even for oily, sensitive, or breakout-prone skin.

So, just how does this superstar ingredient work to deliver supple, healthy-looking, and less-lined skin? The answer is based on the science of skin, and is truly remarkable.

How Does Hyaluronic Acid Benefit Skin?

Hyaluronic Acid is a glycosaminoglycan, a fancy name for a vital natural substance that’s a youth-supporting part of skin. As the chief glycosaminoglycan in skin, Hyaluronic Acid works to keep every aspect of skin stable, safeguarded, and constantly renewed. It also has the stunning capacity to attract and hold vast amounts of moisture.

This science-based magic lies in Hyaluronic Acid’s ability to replenish moisture, a lot of moisture! One gram (0.03 ounce) of Hyaluronic Acid can hold up to six liters of water. Now that really is mind-blowing! But what’s even more impressive is that Hyaluronic Acid can do this for skin without tipping the scales and giving skin too much water. Surprisingly, too much water is a problem for skin because it causes key substances holding skin’s surface intact to break down.

Hyaluronic Acid’s moisture-binding characteristic is exceptionally important when it comes to skin aging. One of the qualities of youthful skin is its ability to hold water and retain a balanced amount of moisture. As we age, our skin loses the ability to maintain this vital, plumping moisture as well as it once did. The result is visible loss of firmness, pliability, and diminished appearance of plumpness and suppleness.

Hyaluronic Acid can enhance moisture content beyond comparison with anything else, and at the same time revitalize skin’s outer layers so they look and feel softer, smoother, and, especially, radiantly hydrated! That’s how it instantly improves the appearance of fine lines and wrinkles


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Ceramosides HP

A unique mixture of Ceramides and DGDG (digalactosyl diglycerides) for visible anti-aging performance. Ceramides and DGDG are extracted from wheat grain from Northeast France removing the wheat germ (gluten) in the process. The result is a phytoceramide that is identical to Ceramides found in the skin. Essential DGDG acts as a performance activator, acting in synergy with ceramides.
Ceramosides HP has no gluten or GMOs.

Clinical Study 1
0.2% of Ceramosides HP vs Placebo. 28 days of treatment; Double blind test; 2 applications daily on face; 53 caucasian volunteers with dull complexion & sagging skin. Participants showed a noticeable improvement in self-esteem after 28 days expressing feelings of joy, increased calm and reduced feelings of sadness and nervousness compared to the placebo group.

Clinical Study 2
Third party evaluations of participants revealed improved skin texture (more consistent) and improved skin color (more uniform) than placebo group. Experienced judges rated the skin quality as improved complexion (clearer), fresher, more homogenous and more matte in appearance. Participants said skin is visibly more: (self evaluations)
RADIANT for 70% of women
FIRM for 74% of women
TONE for 78% of women




Aging Skin

Skin is a complex, multilayered organ with a myriad of functions. The most visible manifestations of skin aging occur mostly in the outermost layers.

To understand how aging changes your skin, we need to review the normal structure of the outer layer of skin, called the stratum corneum, and what becomes of it over time.

The stratum corneum is composed of flattened, hard, dead skin cells that resemble overlapping bricks, which start as living cells in the lower skin layers. As they are pushed closer to the surface, they flatten out and die, providing a thin but very tough barrier. [9]

But these flat cells would flake away immediately if they weren't held together by a kind of flexible skin cement, which is 35 to 40% ceramides. [4] If you think of the stratum corneum cells as bricks, the skin cement is the mortar between them that holds them in place.

Together, these flat cells and the more flexible, lipid-rich cement provide a natural seal that acts as a two-way barrier: it keeps out germs, toxins, and other contaminants, while keeping in moisture to maintain a healthy, flexible, and supple skin texture. [10]

Cells in the stratum corneum are constantly replaced from living cells in the deeper skin layers; the outer layers of skin (ie, epidermis) are replaced roughly every 39 days. [11] And the ceramides and other lipids in the extracellular matrix are constantly replenished by nutrients brought to the deeper skin layers by the bloodstream. [1,2]

At least, that's how it all works in youth.

As we age, our skin, like so many of our other organs, slows down. Studies show that after age 50 or so, new outer layer skin cells take more than 50% longer to reach the surface, an indication of delayed proliferation. [13]

Worse, the amount of specialized lipids in the extracellular matrix declines with age and ceramides are among the first to go. [1-3] As a result, the "cement" that holds the skin cells together is weakened and loses much of its moisture barrier function. [2] Lost moisture results in the dry skin that is common in older adults. [2,14]

Finally, the skin, like every other organ, falls victim to the ravages of chronic oxidant stress and inflammation. [15] Together these omnipresent threats trigger production of enzymes that degrade vital skin proteins. Among their chief targets are collagen, the main structural skin protein, and elastin, which gives skin its suppleness and flexibility. [16]  Chronic exposure to sunlight aggravates these processes. [3,17-19]

One look at a typical older person's skin tells the story. Lost moisture in the stratum corneum leaves the skin surface pale and dry with fine wrinkles. [3] Inflammatory changes can produce itching, redness, and dry patches. Loss of collagen thins the skin, while declining elastin renders it less flexible; these changes produce the larger wrinkles we associate with age.

While topical products aim to replenish skin oils from the outside, the skin's natural sealing agents such as ceramides and other specialized lipids, come from inside the body. They're derived from precursor molecules delivered by the bloodstream, that then make their way up through the deeper skin layers, ultimately being deposited in the stratum corneum. [12] No matter how good your topical skin cream or lotion is, it cannot replace the structural barrier created by ceramides.


1. Saint Leger D, Francois AM, Leveque JL, Stoudemayer TJ, Grove GL, Kligman AM. Age-associated changes in stratum corneum, lipids and their relation to dryness. Dermatologica 1988;177(3): 159-64

2. Rogers J, Harding C, Mayo A, Banks J, Rawlings A. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. 1996 Nov;288(12):765-70.

3. Hashizume H. Skin aging and dry skin. J Dermatol. 2004 Aug;31(8):603-9.

4. Guillou S, Ghabri S, Jannot C, Gaillard E, Lamour I, Boisnic S. The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. Int J Cosmet Sci. 2011 Apr;33(2):138-43.

5. Boisnic S, Beranger JY, Branchet MC. Cutaneous Hydration Evaluation After a Vegetal Ceramide-Based Cream Application on Normal Human Skin Tissue Model Maintained Alive, Submitted to a Dehydration Model HITEX;2003.

6. Boisnic S. Clinical Evaluation of a Hydrating Food Supplement: Double blind randomized study versus placebo: HITEX;2005.

7. Yilmaz E, Borchert HH. Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema—an in vivo study. Int J Pharm. 2006 Jan 13;307(2):232-8.

8. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. Dermatology. 1996;193(2):115-20.

9. Available at: Accessed October 18, 2012.

10. Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006 Dec;1758(12):2080-95. Epub 2006 Jul 11.

11. Weinstein GD, McCullough JL, Ross P. Cell proliferation in normal epidermis. J Invest Dermatol. 1984 Jun;82(6):623-8.

12. Nilsson A, Duan RD. Absorption and lipoprotein transport of sphingomyelin. J Lipid Res. 2006 Jan;47(1):154-71.

13. Grove GL, Kligman AM. Age-associated changes in human epidermal cell renewal. J Gerontol. 1983 Mar;38(2):137-42.

14. Barco D, Gimenez-Arnau A. Xerosis: a dysfunction of the epidermal barrier. Actas Dermosifiliogr. 2008 Nov;99(9):671-82.

15. Mastaloudis A, Wood SM. Age-related changes in cellular protection, purification, and inflammation-related gene expression: role of dietary phytonutrients. Ann N Y Acad Sci. 2012 Jul;1259: 112-20.

16. Robert L, Jacob MP, Frances C, Godeau G, Hornebeck W. Interaction between elastin and elastases and its role in the aging of the arterial wall, skin and other connective tissues. A review. Mech Ageing Dev. 1984 Dec;28(2-3):155-66.

17. Scharffetter-Kochanek K, Brenneisen P, Wenk J, et al. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol. 2000 May;35(3):307-16.

18. Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation - a review. Int J Cosmet Sci. 2005 Feb;27(1):17-34.

19. Liebel F, Kaur S, Ruvolo E, Kollias N, Southall MD. Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes. J Invest Dermatol. 2012 Jul;132(7): 1901-7.

20. Sela BA. Dermatological manifestations of smoking. Harefuah. 2002 Aug;141(8):736-40, 60.

21. Imokawa G. Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase. Arch Dermatol Res. 2008 Apr;300 Suppl 1:S7-20.

22. Imokawa G. Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase. J Investig Dermatol Symp Proc. 2009 Aug;14(1):36-43.Skin